4-(1,1-Dioxido-2-isothiazolidinyl)-1-(phenylmethyl)piperidine → 688020-17-9

HRID 639442Notes

Reaction equation

HRID 639442 reaction equation
[O:1]=[S:2]1(=[O:20])[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:12][CH2:11][N:10](CC2C=CC=CC=2)[CH2:9][CH2:8]1>[OH-].[Pd+2].[OH-].CO>[O:20]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1

Participants

4

Reactant 1

HCID 462231014-(1,1-Dioxido-2-isothiazolidinyl)-1-(phenylmethyl)piperidine

Product 1

HCID 53256087688020-17-9

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

20% Palladium hydroxide (100 mg) was added to the methanol solution (5 mL) containing 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-1-benzylpiperidine (252 mg) at 0° C., followed by stirring at room temperature for 5 hrs. under a hydrogen atmosphere. The reaction mixture was filtered to remove the palladium catalyst, followed by concentration under reduced pressure to give the title compound.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customto remove the palladium catalyst
  3. concentrationfollowed by concentration under reduced pressure

Sources & evidence

ORD record
ord-8989cc46dee44dd7a73021652d3582be
Source dataset
uspto-grants-2010_04
Patent number
US07691860B2

Reaction notes

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