Triethylamine → HCID 59254945, compound

HRID 639445Notes

Reaction equation

HRID 639445 reaction equation
[C:1]([C:3]1([NH2:9])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)#[CH:2].C(N(CC)CC)C.[CH3:17][N:18]=[C:19]=[O:20]>C(#N)C>[C:1]([C:3]1([NH:9][C:19]([NH:18][CH3:17])=[O:20])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)#[CH:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 1216911-Ethynylcyclohexylamine

Product 1

HCID 59254945HCID 59254945, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 1 g (8 mmol) 1-ethynylcyclohexylamine and 2 mL (15 mmol) triethylamine in 10 mL acetonitrile is combined at ambient temperature with 0.5 g (9 mmol) methylisocyanate. The colourless suspension is stirred overnight at ambient temperature and then evaporated down. The residue is taken up in dichloromethane and washed with aqueous potassium carbonate solution. The organic phase is dried and evaporated down. Yield: 1.4 g (colourless solid)

Workup

  1. customevaporated down
  2. washwashed with aqueous potassium carbonate solution
  3. customThe organic phase is dried
  4. customevaporated down

Sources & evidence

ORD record
ord-8fc106243f5c40e79e43ee17c7f63a68
Source dataset
uspto-grants-2010_04
Patent number
US07691868B2

Reaction notes

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