反应详情

温度

0 °C

1-Benzyl-4-benzylamino-6-trifluoromethyl-1,3-dihydro-imidazo[4,5-c]pyridine-2-one (2.63 g, 6.60 mmol) was dissolved in c.H2SO4 (50 ml) and the reaction mixture was stirred at room temperature for 30 minutes. The reaction mixture was cooled to 0° C. and ice was added. K2CO3 (150 g) was dissolved in water (700 ml) and the reaction mixture was added dropwise. The aqueous was extracted with EtOAc (6×500 ml). The combined organics were washed with brine (200 ml), dried over MgSO4 and concentrated in vacuo to give the title compound (1.20 g) as a white solid.

1. additionice was added
2. additionthe reaction mixture was added dropwise
3. extractionThe aqueous was extracted with EtOAc (6×500 ml)
4. washThe combined organics were washed with brine (200 ml)
5. dry with materialdried over MgSO4
6. concentrationconcentrated in vacuo