反应详情

Benzyl-(2-chloro-3-nitro-6-trifluoromethyl-pyridin-4-yl)-amine (3.1 g, 9.3 mmol) was stirred in 5 ml concentrated sulphuric acid for 0.5 h before cautiously pouring the solution into a beaker of crushed ice. Solid K2CO3 was added portion-wise until a basic pH was achieved and the aqueous extracted with 2×50 ml EtOAc. The combined organics were dried over MgSO4 and concentrated in vacuo to afford 2.2 g of the title compound as a pale yellow solid.

1. additionbefore cautiously pouring the solution into a beaker of crushed ice
2. extractionthe aqueous extracted with 2×50 ml EtOAc
3. dry with materialThe combined organics were dried over MgSO4
4. concentrationconcentrated in vacuo