Ammonia → HCID 67456580, compound

HRID 639633Notes

Reaction equation

HRID 639633 reaction equation
[CH2:1]([O:3][C:4](=[O:28])[N:5]([C:14]1[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[N:17]=[C:16](Cl)[C:15]=1[N+:25]([O-:27])=[O:26])[CH2:6][C:7]1[CH:8]=[N:9][C:10]([CH3:13])=[CH:11][CH:12]=1)[CH3:2].[NH3:29]>C1COCC1>[CH2:1]([O:3][C:4](=[O:28])[N:5]([C:14]1[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[N:17]=[C:16]([NH2:29])[C:15]=1[N+:25]([O-:27])=[O:26])[CH2:6][C:7]1[CH:8]=[N:9][C:10]([CH3:13])=[CH:11][CH:12]=1)[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86614476HCID 86614476, compound

Product 1

HCID 67456580HCID 67456580, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(2-Chloro-3-nitro-6-trifluoromethyl-pyridin-4-yl)-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester (54 mg, 0.13 mmol) was dissolved in THF (1 ml) and transferred to a 10 ml reactivial. 880 Ammonia (1 ml) was added, the vessel sealed and the mixture stirred vigorously at ambient temperature for 16 h. The solution was concentrated in vacuo to give a crude oil which was purified directly by column chromatography on silica, eluting with 100% EtOAc to give 27 mg of the title compound as a yellow residue.

Workup

  1. customthe vessel sealed
  2. concentrationThe solution was concentrated in vacuo
  3. customto give a crude oil which
  4. customwas purified directly by column chromatography on silica
  5. washeluting with 100% EtOAc

Sources & evidence

ORD record
ord-560640c779934cf69af975e5104995b3
Source dataset
uspto-grants-2010_04
Patent number
US07691877B2

Reaction notes

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