2-Methoxyethylamine → [2-Amino-6-(2-methoxy-ethylamino)-3-nitro-pyridin-4-yl]-benzyl-carbamic acid ethyl ester

HRID 639669Notes

Reaction equation

[CH3:1][O:2][CH2:3][CH2:4][NH2:5].[CH2:6]([O:8][C:9](=[O:29])[N:10]([C:18]1[CH:23]=[C:22](Br)[N:21]=[C:20]([NH2:25])[C:19]=1[N+:26]([O-:28])=[O:27])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:7]>>[CH2:6]([O:8][C:9](=[O:29])[N:10]([C:18]1[CH:23]=[C:22]([NH:5][CH2:4][CH2:3][O:2][CH3:1])[N:21]=[C:20]([NH2:25])[C:19]=1[N+:26]([O-:28])=[O:27])[CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[CH3:7]

Participants

Reactant 2

HCID 80182-Methoxyethylamine

HCID 86614485(2-Amino-6-bromo-3-nitro-pyridin-4-yl)-benzyl-carbamic acid ethyl ester

Product 1

HCID 67456656[2-Amino-6-(2-methoxy-ethylamino)-3-nitro-pyridin-4-yl]-benzyl-carbamic acid ethyl ester

Procedure

The title compound was prepared following the example in preparation 102 using 2-methoxyethylamine (1.0 ml) and (2-amino-6-bromo-3-nitro-pyridin-4-yl)-benzyl-carbamic acid ethyl ester (150 mg), giving the product (121 mg) as a yellow gum.

Sources & evidence

ORD record: ord-30e1cbe0afd846d3b18ea5189bf4a766
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07691877B2

Reaction notes

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