Ammonia → (2-Amino-6-bromo-3-nitro-pyridin-4-yl)-(6-trifluoromethyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:28])[N:5]([C:17]1[CH:22]=[C:21]([Br:23])[N:20]=[C:19](Br)[C:18]=1[N+:25]([O-:27])=[O:26])[CH2:6][C:7]1[CH:8]=[N:9][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:11][CH:12]=1)[CH3:2].[NH3:29]>>[CH2:1]([O:3][C:4](=[O:28])[N:5]([C:17]1[CH:22]=[C:21]([Br:23])[N:20]=[C:19]([NH2:29])[C:18]=1[N+:25]([O-:27])=[O:26])[CH2:6][C:7]1[CH:8]=[N:9][C:10]([C:13]([F:14])([F:15])[F:16])=[CH:11][CH:12]=1)[CH3:2]Participants
3
Procedure
The title compound was prepared following the example in preparation 69 using (2,6-dibromo-3-nitro-pyridin-4-yl)-(6-trifluoromethyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester (2.75 g), aqueous ammonia (11 ml), and 2-methyl-THF (11 ml). This gave the product (1.92 g) as a yellow oil.
Sources & evidence
- ORD record
- ord-d5b40776288744e3a2c2eb7818d7bd7a
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07691877B2
Reaction notes
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