Potassium tert-butoxide → HCID 86614491, compound

HRID 639681Notes

Reaction equation

HRID 639681 reaction equation
[CH3:1][C:2]([CH3:5])([O-])[CH3:3].[K+].[CH2:7]([N:14]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:15]1[C:20]([N+:21]([O-:23])=[O:22])=[C:19]([NH2:24])[CH:18]=[C:17]([Br:25])[N:16]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C1COCC1>[CH2:26]([N:14]([CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:15]1[C:20]([N+:21]([O-:23])=[O:22])=[C:19]([NH:24][CH2:1][C:2]2[CH:5]=[N:21][C:20]([CH3:15])=[CH:19][CH:3]=2)[CH:18]=[C:17]([Br:25])[N:16]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 86614492HCID 86614492, compound

Product 1

HCID 86614491HCID 86614491, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Potassium tert-butoxide (448 mg) was added portion-wise to a cooled solution (−18° C.—salt/ice bath) of N2,N2-dibenzyl-6-bromo-3-nitro-pyridine-2,4-diamine (1500 mg, 3.63 mmol) in THF (40 ml) under nitrogen. The solution changed from yellow to deep red/orange on addition of base. The solution was left to stir in the cooling bath for 5 minutes.

Workup

  1. additiondeep red/orange on addition of base
  2. waitThe solution was left

Sources & evidence

ORD record
ord-0fc20fb2fc0849be863ff27b0f9ec11b
Source dataset
uspto-grants-2010_04
Patent number
US07691877B2

Reaction notes

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