反应详情

Ethyl isobutyrylacetic acid (21 g, 132 mmol) was taken up in a 1.5M sodium hydroxide solution (15 g in 250 mL water) and stirred at room temperature over 16 h. The solution was cooled to 0° C. in an ice bath and was then acidified with 35 mL conc. Hydrochloric acid to pH 1-2. The resulting solution was saturated with sodium chloride and was then extracted with ethyl acetate (3×300 mL). The combined extracts were dried over sodium sulfate and then filtered and concentrated in vacuo to give the title compound as a clear oil (16.4 g, 95%).

1. temperatureThe solution was cooled to 0° C. in an ice bath
2. extractionwas then extracted with ethyl acetate (3×300 mL)
3. dry with materialThe combined extracts were dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo