1,4-Dibromobutane → HCID 178453977, compound

HRID 639751Notes

Reaction equation

HRID 639751 reaction equation
C(=O)([O-])O.[K+].[NH2:6][C@@H:7]1[CH2:12][CH2:11][C@H:10]([NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:9][CH2:8]1.Br[CH2:22][CH2:23][CH2:24][CH2:25]Br>CN(C=O)C>[N:6]1([C@@H:7]2[CH2:12][CH2:11][C@H:10]([NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:9][CH2:8]2)[CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

5

Reactant 3

HCID 80561,4-DibromobutaneHCID 516893Potassium BicarbonateHCID 178418966HCID 178418966, compound

Product 1

HCID 178453977HCID 178453977, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

25 mg of potassium hydrogen carbonate are added to a solution of tert-butyl cis-4-aminocyclohexanecarbamate (10 g, 46 mmol) and 1,4-dibromobutane (12.1 g, 56 mmol) in 400 ml of DMF, and the mixture is stirred at RT for 24 h. The reaction mixture is then evaporated and the residue is taken up in diethyl ether; this solution is washed with water. The organic phase is dried and evaporated in vacuo. Yield: 12 g.

Workup

  1. customThe reaction mixture is then evaporated
  2. washthis solution is washed with water
  3. customThe organic phase is dried
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-702686739f024d3fa9b456c016143e9f
Source dataset
uspto-grants-2010_04
Patent number
US07691888B2

Reaction notes

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