反应详情

Hydrazine hydrate (0.44 ml, 7.23 mmol) was added to a solution of 2-(methylthio)-4,5,6,7-tetrahydro-1H-1,3-diazepine hydroiodide (1.79 d, 6.58 mmol) in EtOH (12 ml). The reaction mixture was refluxed for 5 h and cooled to r.t. Et2O was added and the product was collected by filtration, washed with Et2O and dried under vacuum to give 1.46 g (100%) crude title compound which was used directly in the next step.

1. temperatureThe reaction mixture was refluxed for 5 h
2. filtrationthe product was collected by filtration
3. washwashed with Et2O
4. customdried under vacuum