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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 639802Generated: October 26, 2026

Sodium hydride → 4-(5-{1-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)pyridine

https://huagongshe.com/reaction/639802

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium hydrideHCID 24758—
Reactant4-[5-(Methanesulfonyl)-4-methyl-4H-1,2,4-triazol-3-yl]pyridineHCID 22151477—
Reactant2-(3-chloro-phenyl)-2H-tetrazol-5-yl-ethanolHCID 59424217—
Product4-(5-{1-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)pyridineHCID 1163237148%

Reaction Steps

The title compound (44.0 mg, 48%, clear oil) was prepared from 1-[2-(3-chloro-phenyl)-2H-tetrazol-5-yl-ethanol (54.3 mg, 0.242 mmol), sodium hydride (12.0 mg, 0.29 mmol) and 4-(5-methanesulfonyl-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine (69.1 mg, 0.29 mmol). 1H NMR (CDCl3) δ (ppm): 8.75 (m, 2H), 8.16 (m, 1H), 8.04 (m, 1H), 7.61 (m, 2H), 7.49 (m, 2H), 6.59 (q, 1H), 3.63 (s, 3H), 2.04 (d, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07691892B2
Source datasetuspto-grants-2010_04
ORD IDord-716d190fa47f41c9a68155a6077cc6e9
Source noteuspto-grants-2010_04