HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 4-(5-{1-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-[5-(Methanesulfonyl)-4-methyl-4H-1,2,4-triazol-3-yl]pyridine | HCID 22151477 | — |
| Reactant | 2-(3-chloro-phenyl)-2H-tetrazol-5-yl-ethanol | HCID 59424217 | — |
| Product | 4-(5-{1-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)pyridine | HCID 11632371 | 48% |
Reaction Steps
The title compound (44.0 mg, 48%, clear oil) was prepared from 1-[2-(3-chloro-phenyl)-2H-tetrazol-5-yl-ethanol (54.3 mg, 0.242 mmol), sodium hydride (12.0 mg, 0.29 mmol) and 4-(5-methanesulfonyl-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine (69.1 mg, 0.29 mmol). 1H NMR (CDCl3) δ (ppm): 8.75 (m, 2H), 8.16 (m, 1H), 8.04 (m, 1H), 7.61 (m, 2H), 7.49 (m, 2H), 6.59 (q, 1H), 3.63 (s, 3H), 2.04 (d, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691892B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-716d190fa47f41c9a68155a6077cc6e9 |
| Source note | uspto-grants-2010_04 |