Sodium hydride → 4-(5-{1-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)pyridine
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([CH:13]([OH:15])[CH3:14])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[H-].[Na+].CS([C:22]1[N:23]([CH3:33])[C:24]([C:27]2[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=2)=[N:25][N:26]=1)(=O)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([CH:13]([O:15][C:22]3[N:23]([CH3:33])[C:24]([C:27]4[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=4)=[N:25][N:26]=3)[CH3:14])=[N:9]2)[CH:5]=[CH:6][CH:7]=1참가 물질
4
실험 절차
The title compound (44.0 mg, 48%, clear oil) was prepared from 1-[2-(3-chloro-phenyl)-2H-tetrazol-5-yl-ethanol (54.3 mg, 0.242 mmol), sodium hydride (12.0 mg, 0.29 mmol) and 4-(5-methanesulfonyl-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine (69.1 mg, 0.29 mmol). 1H NMR (CDCl3) δ (ppm): 8.75 (m, 2H), 8.16 (m, 1H), 8.04 (m, 1H), 7.61 (m, 2H), 7.49 (m, 2H), 6.59 (q, 1H), 3.63 (s, 3H), 2.04 (d, 3H).
출처 및 근거
- ORD 기록
- ord-716d190fa47f41c9a68155a6077cc6e9
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07691892B2
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