Sodium hydride → 4-{5-[2-(2-Fluoro-5-methyl-phenyl)-2H-tetrazol-5-ylmethoxy]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine

HRID 639805Notes

Reaction equation

HRID 639805 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]1[N:13]=[N:12][C:11]([CH2:14][OH:15])=[N:10]1.[H-].[Na+].CS([C:22]1[N:23]([CH3:33])[C:24]([C:27]2[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=2)=[N:25][N:26]=1)(=O)=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]1[N:13]=[N:12][C:11]([CH2:14][O:15][C:22]2[N:23]([CH3:33])[C:24]([C:27]3[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=3)=[N:25][N:26]=2)=[N:10]1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 221514774-(4-Methyl-5-(methylsulfonyl)-4H-1,2,4-triazol-3-yl)pyridineHCID 68431666[2-(2-fluoro-5-methyl-phenyl)-2H-tetrazol-5-yl]-methanol

Product 1

HCID 684323934-{5-[2-(2-Fluoro-5-methyl-phenyl)-2H-tetrazol-5-ylmethoxy]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine

Procedure

The title compound is prepared from [2-(2-fluoro-5-methyl-phenyl)-2H-tetrazol-5-yl]-methanol (1 mmol), sodium hydride (1.5 mmol) and 4-(5-methanesulfonyl-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine (1.25 mmol).

Sources & evidence

ORD record
ord-646dc0bd4ccd45bfb82a241ba407f255
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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