Sodium hydride → 4-{5-[2-(3-Chloro-phenyl)-2H-tetrazol-5-ylmethoxy]-4-cyclopropyl-4H-[1,2,4]triazol-3-yl}-pyridine

HRID 639807Notes

Reaction equation

HRID 639807 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([CH2:13][OH:14])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[H-].[Na+].[CH:17]1([N:20]2[C:24](S(C)(=O)=O)=[N:23][N:22]=[C:21]2[C:29]2[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=2)[CH2:19][CH2:18]1>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([CH2:13][O:14][C:24]3[N:20]([CH:17]4[CH2:19][CH2:18]4)[C:21]([C:29]4[CH:30]=[CH:31][N:32]=[CH:33][CH:34]=4)=[N:22][N:23]=3)=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 578379334-(4-Cyclopropyl-5-methanesulfonyl-4H-[1,2,4]triazol-3-yl)-pyridineHCID 59424225[2-(3-Chloro-phenyl)-2H-tetrazol-5-yl]-methanol

Product 1

HCID 115167534-{5-[2-(3-Chloro-phenyl)-2H-tetrazol-5-ylmethoxy]-4-cyclopropyl-4H-[1,2,4]triazol-3-yl}-pyridine

Procedure

The title compound is prepared from [2-(3-chloro-phenyl)-2H-tetrazol-5-yl]-methanol (1 mmol), sodium hydride (1.5 mmol) and 4-(4-cyclopropyl-5-methanesulfonyl-4H-[1,2,4]triazol-3-yl)-pyridine (1.25 mmol).

Sources & evidence

ORD record
ord-499718aa45354626ba3e378d6ac89e6b
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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