反应详情

m-CPBA (10 g, 33-50 mmol, 57-86% pure) was added to a solution of 3-(3,5-difluorophenyl)-4-methyl-5-(methylthio)-4H-1,2,4-triazole (4.9 g, 20.3 mmol) in DCM (60 mL) and the reaction was stirred o.n. 2M NaOH (50 mL) was added and the mixture was extracted. The water phase was re-extracted with EtOAc (2×) and the combined organic phases were dried (MgSO4) and evaporated to give 5.4 g (98%) of the title compound.

1. extractionthe mixture was extracted
2. extractionThe water phase was re-extracted with EtOAc (2×)
3. dry with materialthe combined organic phases were dried (MgSO4)
4. customevaporated