Hydrochloric Acid → HCID 59424222、化合物

関与物質

反応手順

1.25 g (4.68 mmol) (1R)-1-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]ethyl acetate and 0.48 g (11.4 mmol) lithium hydroxide monohydrate were mixed with 3:1 THF/Water (28 mL) and stirred for 20 h. After acidification with aq. HCl, followed by reducing the volume of the mixture in vacuo, followed by dilution with brine and extraction with DCM. 5.8 g (97%) of the title compound was obtained after evaporation & coevaporation with toluene, followed by drying. 1H NMR: 8.15 (m, 1H), 8.03 (m, 1H), 7.48 (m, 2H), 6.27 (q, 1H), 2.14 (s, 3H), 1.77 (d, 3H).

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