Hydrochloric Acid → HCID 59424222, 화합물

HRID 639837노트

반응식

HRID 639837 반응식
C([O:4][C@@H:5]([C:7]1[N:8]=[N:9][N:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[N:11]=1)[CH3:6])(=O)C.O.[OH-].[Li+].Cl>C1COCC1.O>[Cl:18][C:14]1[CH:13]=[C:12]([N:10]2[N:9]=[N:8][C:7]([C@H:5]([OH:4])[CH3:6])=[N:11]2)[CH:17]=[CH:16][CH:15]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 59424210(1R)-1-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]ethyl acetate

생성물 1

HCID 59424222HCID 59424222, 화합물수율 551.7%

시약·촉매·용매 1

HCID 21881883Oxolane--water (1/1)용매

실험 절차

1.25 g (4.68 mmol) (1R)-1-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]ethyl acetate and 0.48 g (11.4 mmol) lithium hydroxide monohydrate were mixed with 3:1 THF/Water (28 mL) and stirred for 20 h. After acidification with aq. HCl, followed by reducing the volume of the mixture in vacuo, followed by dilution with brine and extraction with DCM. 5.8 g (97%) of the title compound was obtained after evaporation & coevaporation with toluene, followed by drying. 1H NMR: 8.15 (m, 1H), 8.03 (m, 1H), 7.48 (m, 2H), 6.27 (q, 1H), 2.14 (s, 3H), 1.77 (d, 3H).

후처리

  1. extractionfollowed by dilution with brine and extraction with DCM

출처 및 근거

ORD 기록
ord-cd975243caf74151ae124ee1ff51a672
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691892B2

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