Ethyl Acrylate → HCID 15696577, compound

HRID 639847Notes

Reaction equation

HRID 639847 reaction equation
[NH2:1][CH:2]([CH3:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:10]([O:14][CH2:15][CH3:16])(=[O:13])[CH:11]=[CH2:12]>CCO>[CH2:15]([O:14][C:10](=[O:13])[CH2:11][CH2:12][NH:1][CH:2]([CH3:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:16]

Participants

4

Reactant 2

HCID 8821Ethyl AcrylateHCID 98103Ethyl 3-aminobutyrate

Product 1

HCID 15696577HCID 15696577, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of ethyl 3-aminobutanoate (4.2 g) and of ethyl 2-propenoate (3.83 mL) in EtOH (20 mL) was stirred at room temperature for 8 h. The solvent was evaporated under reduced pressure and the residue purified by chromatography on NH column eluting with a gradient from 100% cyclohexane to 90% ethyl acetate/cyclohexane. The title compound was isolated as a colourless oil, 3.9 g (MS (m/z): 232 [MH]+.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue purified by chromatography on NH column
  3. washeluting with a gradient from 100% cyclohexane to 90% ethyl acetate/cyclohexane

Sources & evidence

ORD record
ord-266854fc87104b09ac26d16514c66928
Source dataset
uspto-grants-2010_04
Patent number
US07691893B2

Reaction notes

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