反应详情

A solution of ethyl 3-aminobutanoate (4.2 g) and of ethyl 2-propenoate (3.83 mL) in EtOH (20 mL) was stirred at room temperature for 8 h. The solvent was evaporated under reduced pressure and the residue purified by chromatography on NH column eluting with a gradient from 100% cyclohexane to 90% ethyl acetate/cyclohexane. The title compound was isolated as a colourless oil, 3.9 g (MS (m/z): 232 [MH]+.

1. customThe solvent was evaporated under reduced pressure
2. customthe residue purified by chromatography on NH column
3. washeluting with a gradient from 100% cyclohexane to 90% ethyl acetate/cyclohexane