反应详情

To a stirred solution of 4-oxo-3-piperidinecarboxylate (5 g) in dry DCM (50 ml), under N2 atmosphere, TEA (9 mL) was added at rt and then, at 0° C., benzylchloroformate (4.2 mL) was added slowly and stirring was continued for 30 minutes at 0° C. and 1 h at RT. The mixture was quenched at 0° C. with HCl 2N. The aqueous phase was extracted with DCM (2 times) and the combined organic layers were washed with saturated NaCl aqueous solution, dried and concentrated in vacuo to give the title compound (7.5 g).

1. customThe mixture was quenched at 0° C. with HCl 2N
2. extractionThe aqueous phase was extracted with DCM (2 times)
3. washthe combined organic layers were washed with saturated NaCl aqueous solution
4. customdried
5. concentrationconcentrated in vacuo