Hydrochloric Acid → HCID 75234083, compound

HRID 639861Notes

Reaction equation

HRID 639861 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]23[CH2:15][C:14]2([CH2:16][O:17][CH2:18][CH3:19])[CH2:13][NH:12][CH2:11][CH2:10]3)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl>C(Cl)Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:9]23[CH2:15][C:14]2([CH2:16][O:17][CH2:18][CH3:19])[CH2:13][NH:12][CH2:11][CH2:10]3)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 56657240HCID 56657240, compound

Product 1

HCID 75234083HCID 75234083, compoundYield 147.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (1S,6R or 1R,6S)-6-(3,4-dichlorophenyl)-1-[(ethyloxy)methyl]-3-azabicyclo[4.1.0]heptane (E20a, 7 mg) in DCM (0.2 ml) was added 1 equivalent of HCl (1M in Et2O), the solvent evaporated under vacuo and the material thus obtained triturated with Et2O to give 5.8 mg of the title compound as a white slightly hygroscopic solid.

Workup

  1. customthe solvent evaporated under vacuo
  2. customthe material thus obtained
  3. customtriturated with Et2O

Sources & evidence

ORD record
ord-a1a61ebb8844403aa6cb42f3bb11f12e
Source dataset
uspto-grants-2010_04
Patent number
US07691893B2

Reaction notes

Loading…