Hydrochloric Acid → HCID 77516535, compound

HRID 639862Notes

Reaction equation

HRID 639862 reaction equation
[CH3:1][O:2][CH2:3][C:4]12[CH2:10][C:9]1([C:11]1[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=1)[CH2:8][CH2:7][NH:6][CH2:5]2.[ClH:21]>C(Cl)Cl>[ClH:21].[CH3:1][O:2][CH2:3][C:4]12[CH2:10][C:9]1([C:11]1[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=1)[CH2:8][CH2:7][NH:6][CH2:5]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 56660731HCID 56660731, compound

Product 1

HCID 77516535HCID 77516535, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (1R,6S or 1S,6R)-1-[(methyloxy)methyl]-6-(2-naphthalenyl)-3-azabicyclo[4.1.0]heptane (E26a, 52 mg) in DCM was added 1 equivalent of HCl (1M in Et2O), the solvent evaporated in vacuo and the material thus obtained triturated with Et2O to give 53 mg of the title compound as a white solid.

Workup

  1. customthe solvent evaporated in vacuo
  2. customthe material thus obtained
  3. customtriturated with Et2O

Sources & evidence

ORD record
ord-942de3b7f91c41c4a7dcac8a11f73e73
Source dataset
uspto-grants-2010_04
Patent number
US07691893B2

Reaction notes

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