Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamine → 1-[6-Methoxy-1-(methylsulfonyl)-4-phenylisoquinolin-3-yl]-n,n-dimethylmethanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamine | HCID 11738916 | — |
| 반응물 | HCID 178504973 | HCID 178504973 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-[6-Methoxy-1-(methylsulfonyl)-4-phenylisoquinolin-3-yl]-n,n-dimethylmethanamine | HCID 11462849 | — |
반응 단계
A mixture of 1-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamine (75 mg), 1 mL DMF, and MeSO2Na (41 mg) was stirred at 80 C for 48 h, then at 100 C for 96 h. The solution was cooled and purified directly by reverse-phase HPLC to give the titled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07691879B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-0a0a946d7c5749b1aebd3fceb7a49715 |
| 출처 메모 | uspto-grants-2010_04 |