HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamine → 3-[(Dimethylamino)methyl]-6-methoxy-4-phenylisoquinoline-1-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamine | HCID 11738916 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-[(Dimethylamino)methyl]-6-methoxy-4-phenylisoquinoline-1-carbonitrile | HCID 11255584 | — |
Reaction Steps
A mixture of 1-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamine (31 mg), 1 mL DMSO, and 16 mg CuCN was stirred at 140 C for 3 h. The solution was cooled and purified directly by reverse-phase HPLC to give the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691879B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-5b91032d9a864e44971efc9f0402ff61 |
| Source note | uspto-grants-2010_04 |