Hydrochloric Acid → HCID 68516954, compound

HRID 639883Notes

Reaction equation

HRID 639883 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9]([NH:13][CH2:14][CH2:15][NH:16]C(=O)OC(C)(C)C)=[N:8][C:7]([CH3:24])=[C:6]2[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[ClH:31]>>[Cl-:31].[Cl-:31].[NH3+:16][CH2:15][CH2:14][NH:13][C:9]1[C:10]2[C:5](=[CH:4][C:3]([O:2][CH3:1])=[CH:12][CH:11]=2)[C:6]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[C:7]([CH3:24])[NH+:8]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68520331HCID 68520331, compound

Product 1

HCID 68516954HCID 68516954, compound

Procedure

Tert-butyl 2-[(6-methoxy-3-methyl-4-phenylisoquinolin-1-yl)amino]ethylcarbamate (0.61 g) was treated with 100 mL of HCl-saturated EtOAc. The reaction was stirred at 0 C for 30 min, then at room temp for 3.5 h, then concentrated to dryness. Recrystallization from methanol/EtOAc provided the titled compound.

Workup

  1. waitat room temp for 3.5 h
  2. concentrationconcentrated to dryness
  3. customRecrystallization from methanol/EtOAc

Sources & evidence

ORD record
ord-f0805f75d9224da5b55fc62d9faeeffe
Source dataset
uspto-grants-2010_04
Patent number
US07691879B2

Reaction notes

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