化工社化工社 化学情報印刷レポート · 研究参考用
Allylamine → HCID 11358963、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Allylamine | HCID 7853 | — |
| 反応物 | 1-Chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile | HCID 11426414 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | HCID 11358963 | HCID 11358963 | — |
反応手順
To a suspension of 104 mg of 1-chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile in nBuOH was added 252 uL of allylamine. The reaction was heated at 210 C in a microwave reactor for 1 h, then partitioned between EA and saturated aqueous sodium bicarbonate. The organic solution was washed with brine once, then dried (Na2SO4) and concentrated. Flash chromatography (540% EA/hex, Gilson, 40 g silica) gave a pink solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07691879B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-da367689e4f346b0acee7b07dccadacd |
| 出典メモ | uspto-grants-2010_04 |