反应详情

To a suspension of 104 mg of 1-chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile in nBuOH was added 252 uL of allylamine. The reaction was heated at 210 C in a microwave reactor for 1 h, then partitioned between EA and saturated aqueous sodium bicarbonate. The organic solution was washed with brine once, then dried (Na2SO4) and concentrated. Flash chromatography (540% EA/hex, Gilson, 40 g silica) gave a pink solid.

1. temperatureThe reaction was heated at 210 C in a microwave reactor for 1 h
2. custompartitioned between EA and saturated aqueous sodium bicarbonate
3. washThe organic solution was washed with brine once
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated
6. customFlash chromatography (540% EA/hex, Gilson, 40 g silica) gave a pink solid