Ammonia → HCID 11162174, 화합물

HRID 639900노트

반응식

HRID 639900 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=2)=[C:4]([C:21]#[N:22])[N:3]=1.[NH3:23]>C(O)(C)C>[NH2:23][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=2)=[C:4]([C:21]#[N:22])[N:3]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 112438971-Chloro-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile

생성물 1

HCID 11162174HCID 11162174, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A suspension of 1-chloro-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile in 1.5 mL of 2M NH3 in isopropanol was heated in a sealed tube at 90 C overnight, then heated in a microwave reactor at 170 C for 24 h. The reaction was concentrated and purified by reverse-phase HPLC to give a white solid.

후처리

  1. temperaturewas heated in a sealed tube at 90 C overnight
  2. temperatureheated in a microwave reactor at 170 C for 24 h
  3. concentrationThe reaction was concentrated
  4. custompurified by reverse-phase HPLC
  5. customto give a white solid

출처 및 근거

ORD 기록
ord-5d0a7459ee664255a3da529125a165bb
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691879B2

반응 노트

불러오는 중…