HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ammonia → HCID 11162174, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ammonia | HCID 222 | — |
| Edukt | 1-Chloro-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile | HCID 11243897 | — |
| Lösungsmittel | Isopropanol | HCID 3776 | — |
| Produkt | HCID 11162174 | HCID 11162174 | — |
Reaktionsschritte
A suspension of 1-chloro-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile in 1.5 mL of 2M NH3 in isopropanol was heated in a sealed tube at 90 C overnight, then heated in a microwave reactor at 170 C for 24 h. The reaction was concentrated and purified by reverse-phase HPLC to give a white solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07691879B2 |
| Quelldatensatz | uspto-grants-2010_04 |
| ORD ID | ord-5d0a7459ee664255a3da529125a165bb |
| Quellennotiz | uspto-grants-2010_04 |