1,4-Dioxan-2-ylmethanamine → 1-[(1,4-Dioxan-2-ylmethyl)amino]-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile

HRID 639903Notes

Reaction equation

HRID 639903 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=3)[C:11]([NH:20][CH2:21][CH2:22][OH:23])=[N:10][C:9]=2[C:24]#[N:25])[CH:5]=[CH:6][CH:7]=1.[O:26]1[CH2:31]CO[CH2:28][CH:27]1CN>>[O:23]1[CH2:28][CH2:27][O:26][CH2:31][CH:22]1[CH2:21][NH:20][C:11]1[C:12]2[C:17](=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=2)=[C:9]([C:24]#[N:25])[N:10]=1

Participants

3

Reactant 2

HCID 37480641,4-Dioxan-2-ylmethanamineHCID 114391214-(3-Fluorophenyl)-1-[(2-hydroxyethyl)amino]-6-methoxyisoquinoline-3-carbonitrile

Product 1

HCID 114407801-[(1,4-Dioxan-2-ylmethyl)amino]-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile

Procedure

Following the procedure for 4-(3-fluorophenyl)-1-[(2-hydroxyethyl)amino]-6-methoxyisoquinoline-3-carbonitrile, using 1,4-dioxan-2-ylmethylamine in place of 2-aminoethanol, the title compound was synthesized.

Sources & evidence

ORD record
ord-441a3f924d4f47d0becf19590b6cfb6d
Source dataset
uspto-grants-2010_04
Patent number
US07691879B2

Reaction notes

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