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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 639903Generated: October 25, 2026

1,4-Dioxan-2-ylmethanamine → 1-[(1,4-Dioxan-2-ylmethyl)amino]-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile

https://huagongshe.com/reaction/639903

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxan-2-ylmethanamineHCID 3748064—
Reactant4-(3-Fluorophenyl)-1-[(2-hydroxyethyl)amino]-6-methoxyisoquinoline-3-carbonitrileHCID 11439121—
Product1-[(1,4-Dioxan-2-ylmethyl)amino]-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrileHCID 11440780—

Reaction Steps

Following the procedure for 4-(3-fluorophenyl)-1-[(2-hydroxyethyl)amino]-6-methoxyisoquinoline-3-carbonitrile, using 1,4-dioxan-2-ylmethylamine in place of 2-aminoethanol, the title compound was synthesized.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07691879B2
Source datasetuspto-grants-2010_04
ORD IDord-441a3f924d4f47d0becf19590b6cfb6d
Source noteuspto-grants-2010_04