2-Pyridinemethanamine → 6-Methoxy-4-phenyl-1-[(pyridin-2-ylmethyl)amino]isoquinoline-3-carbonitrile

HRID 639908Notes

Reaction equation

HRID 639908 reaction equation
[CH2:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:15][CH3:16])=[CH:12][CH:13]=2)[C:8]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:7]([C:23]#[N:24])[N:6]=1)[CH:2]=[CH2:3].[N:25]1C=C[CH:28]=[CH:27][C:26]=1CN>>[CH3:16][O:15][C:11]1[CH:10]=[C:9]2[C:14](=[CH:13][CH:12]=1)[C:5]([NH:4][CH2:1][C:2]1[CH:3]=[CH:28][CH:27]=[CH:26][N:25]=1)=[N:6][C:7]([C:23]#[N:24])=[C:8]2[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 195092-PyridinemethanamineHCID 11358963(Allylamino)-6-methoxy-4-phenylisoquinoline-3-carbonitrile

Product 1

HCID 112339186-Methoxy-4-phenyl-1-[(pyridin-2-ylmethyl)amino]isoquinoline-3-carbonitrile

Procedure

Following the procedure for 1-(allylamino)-6-methoxy-4-phenylisoquinoline-3-carbonitrile, using (pyridin-2-ylmethyl)amine in place of allylamine and heating for 35 min instead of 1 h, the title compound was synthesized.

Workup

  1. temperatureheating for 35 min instead of 1 h

Sources & evidence

ORD record
ord-f6e263d54b774ec0928c33326666eb8b
Source dataset
uspto-grants-2010_04
Patent number
US07691879B2

Reaction notes

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