1-Chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile → 1-Chloro-4-(2-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile

HRID 639911Notes

Reaction equation

HRID 639911 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:4]([C:20]#[N:21])[N:3]=1.COC1C=C2C(=CC=1)C(=O)NC(C#N)=C2C1C=CC=CC=1[F:43]>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:43])=[C:4]([C:20]#[N:21])[N:3]=1

Participants

3

Reactant 2

HCID 114264141-Chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrileHCID 68518357HCID 68518357, compound

Product 1

HCID 113359631-Chloro-4-(2-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile

Procedure

Following the procedure for 1-chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile, using 6-methoxy-1-oxo-4-(2-fluorophenyl)-1,2-dihydroisoquinoline-3-carbonitrile in place of 6-methoxy-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile, the title compound was synthesized.

Sources & evidence

ORD record
ord-e9bce5b3378a4a0f8a4086559dc432d4
Source dataset
uspto-grants-2010_04
Patent number
US07691879B2

Reaction notes

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