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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 639911Generated: October 30, 2026

1-Chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile → 1-Chloro-4-(2-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile

https://huagongshe.com/reaction/639911

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrileHCID 11426414—
ReactantHCID 68518357HCID 68518357—
Product1-Chloro-4-(2-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrileHCID 11335963—

Reaction Steps

Following the procedure for 1-chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile, using 6-methoxy-1-oxo-4-(2-fluorophenyl)-1,2-dihydroisoquinoline-3-carbonitrile in place of 6-methoxy-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile, the title compound was synthesized.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07691879B2
Source datasetuspto-grants-2010_04
ORD IDord-e9bce5b3378a4a0f8a4086559dc432d4
Source noteuspto-grants-2010_04