4-(3-Fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile → 4-(2-Fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile

HRID 639912Notes

Reaction equation

HRID 639912 reaction equation
FC1C=C(C2C3C(=CC=C(OC)C=3)C=NC=2C#N)C=CC=1.Cl[C:23]1[C:32]2[C:27](=[CH:28][C:29]([O:33][CH3:34])=[CH:30][CH:31]=2)[C:26]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=2[F:41])=[C:25]([C:42]#[N:43])[N:24]=1.ClC1C2C(=CC(OC)=CC=2)C(C2C=CC=C(F)C=2)=C(C#N)N=1>>[F:41][C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=1[C:26]1[C:27]2[C:32](=[CH:31][CH:30]=[C:29]([O:33][CH3:34])[CH:28]=2)[CH:23]=[N:24][C:25]=1[C:42]#[N:43]

Participants

4

Reactant 3

HCID 111501214-(3-Fluorophenyl)-6-methoxyisoquinoline-3-carbonitrileHCID 112438971-Chloro-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrileHCID 113359631-Chloro-4-(2-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile

Product 1

HCID 117375134-(2-Fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile

Procedure

Following the procedure for 4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, using 1-chloro-4-(2-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile in place 1-chloro-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, the title compound was synthesized.

Sources & evidence

ORD record
ord-7219114d5e034d71b092d487bf597459
Source dataset
uspto-grants-2010_04
Patent number
US07691879B2

Reaction notes

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