Hydrochloric Acid → HCID 68519727, compound

HRID 639928Notes

Reaction equation

HRID 639928 reaction equation
[C:1]([C:3]1[N:4]=[C:5]([C:21]([O:23]C)=[O:22])[C:6]2[C:11]([C:12]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)=[CH:10][C:9]([O:19][CH3:20])=[CH:8][CH:7]=2)#[N:2].[OH-].[Na+].O.Cl>CCO>[C:1]([C:3]1[N:4]=[C:5]([C:21]([OH:23])=[O:22])[C:6]2[C:11]([C:12]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)=[CH:10][C:9]([O:19][CH3:20])=[CH:8][CH:7]=2)#[N:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 68518415HCID 68518415, compound

Product 1

HCID 68519727HCID 68519727, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
0 °C

Procedure

To a suspension of methyl 3-cyano-6-methoxy-4-pyridin-2-ylisoquinoline-1-carboxylate (0.04 g, 0.125 mmol) in 3 mL EtOH, was added 0.251 mL 1(N) aqueous NaOH and 1.16 mL water. The reaction was stirred at 0° C. for 4 h and then 1(N) aqueous HCl (0.251 mL) was added. The reaction was warmed up to rt and concentrated to a tan solid (used without further purification).

Workup

  1. temperatureThe reaction was warmed up to rt
  2. concentrationconcentrated to a tan solid (used without further purification)

Sources & evidence

ORD record
ord-5078257b88334fdd84c55fe46960ca29
Source dataset
uspto-grants-2010_04
Patent number
US07691879B2

Reaction notes

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