Triethyl phosphite → HCID 86620235, compound

HRID 639940Notes

Reaction equation

HRID 639940 reaction equation
[P:1]([O:8][CH2:9][CH3:10])([O:5][CH2:6][CH3:7])[O:2]CC.[CH2:11]([O:18][C:19]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([CH2:34][CH3:35])=[CH:30][CH:29]=2)=[CH:23][C:20]=1[CH2:21]Cl)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:9]([O:8][P:1]([CH2:21][C:20]1[CH:23]=[C:24]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([CH2:34][CH3:35])=[CH:30][CH:29]=2)[CH:25]=[CH:26][C:19]=1[O:18][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:2])[O:5][CH2:6][CH3:7])[CH3:10]

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 68420425HCID 68420425, compound

Product 1

HCID 86620235HCID 86620235, compound

Conditions

Temperature
155 °C

Procedure

Triethyl phosphite (0.6 mL) was added to 2-benzyloxy-5-(4-ethylbenzyl)benzylchloride (1.00 g), and the mixture was stirred for 4 hr at 150-160° C. The mixture was purified by silica gel column chromatography (ethyl acetate/n-hexane=1/2) to give the title compound (1.09 g) as a colorless oil.

Workup

  1. customThe mixture was purified by silica gel column chromatography (ethyl acetate/n-hexane=1/2)

Sources & evidence

ORD record
ord-a7876ab0176a459297774885c1dab86b
Source dataset
uspto-grants-2010_04
Patent number
US07691898B2

Reaction notes

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