Triethyl phosphite → HCID 86620237, compound

HRID 639943Notes

Reaction equation

HRID 639943 reaction equation
[P:1]([O:8][CH2:9][CH3:10])([O:5][CH2:6][CH3:7])[O:2]CC.[CH2:11]([C:13]1[CH:28]=[CH:27][C:16]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([F:26])=[C:22]([CH:25]=2)[CH2:23]Cl)=[CH:15][CH:14]=1)[CH3:12]>>[CH2:9]([O:8][P:1]([CH2:23][C:22]1[CH:25]=[C:18]([CH2:17][C:16]2[CH:15]=[CH:14][C:13]([CH2:11][CH3:12])=[CH:28][CH:27]=2)[CH:19]=[CH:20][C:21]=1[F:26])(=[O:2])[O:5][CH2:6][CH3:7])[CH3:10]

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 68421454HCID 68421454, compound

Product 1

HCID 86620237HCID 86620237, compound

Conditions

Temperature
155 °C

Procedure

Triethyl phosphite (0.8 mL) was added to [5-(4-ethylbenzyl)-2-fluorobenzyl chloride (0.65 g), and the mixture was stirred for 16 hr at 150-160° C. The mixture was purified by silica gel column chromatography (ethyl acetate/n-hexane=1/1) to give the title compound (0.70 g) as a colorless oil.

Workup

  1. customThe mixture was purified by silica gel column chromatography (ethyl acetate/n-hexane=1/1)

Sources & evidence

ORD record
ord-d43711f497454acba0979879b7f48325
Source dataset
uspto-grants-2010_04
Patent number
US07691898B2

Reaction notes

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