Hydrochloric Acid → HCID 59256054, compound

HRID 639955Notes

Reaction equation

HRID 639955 reaction equation
C([O:3][P:4]([CH2:9][C:10]1[S:14][C:13]2[CH:15]=[CH:16][C:17]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][CH3:27])=[CH:22][CH:21]=3)=[CH:18][C:12]=2[CH:11]=1)(=[O:8])[O:5]CC)C.Cl>C(O)C>[CH2:26]([C:23]1[CH:24]=[CH:25][C:20]([CH2:19][C:17]2[CH:16]=[CH:15][C:13]3[S:14][C:10]([CH2:9][P:4](=[O:3])([OH:5])[OH:8])=[CH:11][C:12]=3[CH:18]=2)=[CH:21][CH:22]=1)[CH3:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86620245HCID 86620245, compound

Product 1

HCID 59256054HCID 59256054, compoundYield 78.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of [5-(4-ethylbenzyl)benzo[b]thiophen-2-ylmethyl]phosphonic acid diethylester (0.80 g) in ethanol (8.0 mL) was added 6N—HCl (8.0 mL), and the reaction mixture was refluxed for 42 hr. Evaporation and crystallization from ethyl acetate-n-hexane gave the title compound (0.54 g) as a colorless crystal.

Workup

  1. temperaturethe reaction mixture was refluxed for 42 hr
  2. customEvaporation and crystallization from ethyl acetate-n-hexane

Sources & evidence

ORD record
ord-6706721190664db4aed61239ff7d030a
Source dataset
uspto-grants-2010_04
Patent number
US07691898B2

Reaction notes

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