tert-Butyl 2-(4-nitro-1H-pyrazol-1-yl)acetate → tert-butyl 2-(4-amino-1H-pyrazol-1-yl)acetate

HRID 640006Notes

Reaction equation

HRID 640006 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([CH2:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:8]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([CH2:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:8]=1

Participants

4

Reactant 1

HCID 50999842tert-Butyl 2-(4-nitro-1H-pyrazol-1-yl)acetate

Product 1

HCID 61285781tert-butyl 2-(4-amino-1H-pyrazol-1-yl)acetateYield 99%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Tert-butyl (4-nitro-1H-pyrazol-1-yl)acetate (1.0 g, 4.40 mmol) and 10% palladium on carbon (0.100 g) in methanol (20 ml) were stirred under an atmosphere of hydrogen for 2 hours and then the mixture was filtered through Celite and the filtrate evaporated to give tert-butyl (4-amino-1H-pyrazol-1-yl)acetate

Workup

  1. filtrationthe mixture was filtered through Celite
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-5975857cff094ac4882ab5a9ca9e10f4
Source dataset
uspto-grants-2010_04
Patent number
US07691867B2

Reaction notes

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