Hydrochloric Acid → HCID 67330534, compound

HRID 64020Notes

Reaction equation

HRID 64020 reaction equation
CO.[F:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:16]1[CH:21]=[CH:20][N:19]2[N:22]=[CH:23][C:24]([NH:25][C:26](=[O:34])[C:27]3[C:32]([CH3:33])=[CH:31][CH:30]=[CH:29][N:28]=3)=[C:18]2[N:17]=1.[ClH:35]>O1CCOCC1>[ClH:35].[F:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:16]1[CH:21]=[CH:20][N:19]2[N:22]=[CH:23][C:24]([NH:25][C:26](=[O:34])[C:27]3[C:32]([CH3:33])=[CH:31][CH:30]=[CH:29][N:28]=3)=[C:18]2[N:17]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 46188749HCID 46188749, compound

Product 1

HCID 67330534HCID 67330534, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a methanol (1 mL) solution of (R)—N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-methylpicolinamide (10.3 mg, 0.0237 mmol) was added HCl as a solution is dioxane (30 μL). After 30 minutes, the reaction was concentrated to provide (R)—N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-methylpicolinamide hydrochloride as a yellow solid.

Workup

  1. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-3285ff5b19c545d8b9580509a8f7f115
Source dataset
uspto-grants-2016_09
Patent number
US09447104B2

Reaction notes

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