反应详情

温度

40 °C

A 28% ammonia aqueous solution (1563 ml) was added to an aqueous solution (500 ml) of (1S,3S,4S)-3-hydroxy-4-bromo-N,N-dimethylcyclohexanecarboxamide (274.5 g), and the obtained solution was then heated to 40° C., followed by stirring the reaction solution for 8 hours. Thereafter, the reaction solution was further stirred at room temperature for 6 hours. Thereafter, 48% sodium hydroxide (67.3 ml) was added to the reaction mixture, and the obtained mixture was then concentrated to 500 ml to obtain the title compound (184.0 g, yield: 81%) in the form of an aqueous solution (572 g).

1. stirringThereafter, the reaction solution was further stirred at room temperature for 6 hours
2. concentrationthe obtained mixture was then concentrated to 500 ml