反应详情

温度

40 °C

A 28% ammonia aqueous solution (125 mL) was added to an aqueous solution (50 mL) of (1S,3S,4S)-3-hydroxy-4-bromo-N,N-dimethylcyclohexanecarboxamide (21.84 g), and the obtained solution was then heated to 40° C., followed by stirring the reaction solution for 8 hours. Thereafter, the reaction solution was further stirred at room temperature for 6 hours. Thereafter, the reaction mixture was concentrated to 50 mL to obtain 14.33 g of the title compound (yield: 79%) in the form of an aqueous solution (49 g).

1. stirringThereafter, the reaction solution was further stirred at room temperature for 6 hours
2. concentrationThereafter, the reaction mixture was concentrated to 50 mL