反应详情

To a carbon tetrachloride (10 mL) solution of (5-benzyloxy-pyridin-2-yl)-methanol (500 mg) described in Manufacturing Example 127-1-2 was added triphenylphosphine (791 mg), which was refluxed for 19 hours and 35 minutes under nitrogen atmosphere. The reaction mixture was cooled to room temperature and then concentrated under a reduced pressure, and the residue was purified by silica gel column chromatography (heptane:ethyl acetate=3:1) to obtain the title compound (386 mg).

1. temperaturewas refluxed for 19 hours and 35 minutes under nitrogen atmosphere
2. concentrationconcentrated under a reduced pressure
3. customthe residue was purified by silica gel column chromatography (heptane:ethyl acetate=3:1)