Triethylamine → HCID 79353504, compound

To a mixture of 4-bromo-2-methylbutan-2-ol (0.4 g, 2.4 mmol) and triethylamine (1 ml, 7 mmol, 3 eq.) in CH2Cl2 (15 ml) was added sodium azide (0.47 g, 7 mmol, 3 eq.) in H2O (5 ml) and the mixture was allowed to stir overnight. The mixture was quenched with water and extracted with CH2Cl2 (3×50 ml). The combined organic layer was washed with water, brine and dried over sodium sulphate. The solvent was distilled off to afford the product in 65% yield (0.2 g). 1H NMR (300 MHz, DMSO-d6): δ 4.39 (br s, 1H), 3.40-3.32 (m, 2H), 1.15 (t, 2H), 1.23-1.04 (m, 6H).

1. customThe mixture was quenched with water
2. extractionextracted with CH2Cl2 (3×50 ml)
3. washThe combined organic layer was washed with water, brine
4. dry with materialdried over sodium sulphate
5. distillationThe solvent was distilled off
6. customto afford the product in 65% yield (0.2 g)

ORD record

ord-dd7b74afc2384757924d3becd2a98537

Source dataset

uspto-grants-2016_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09447091B2