反应详情

The solution of ethyl 2-(pyrrolidin-1-yl)acetate (2 g, 12.7 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 91% yield (1.5 g). LC-MS (ESI): Calculated mass: 129.1; Observed mass 130.1 [M+H+] (rt: 0.26 min).

1. concentrationThe mixture was concentrated
2. customquenched
3. extractionextracted as in Intermediate Example 15(b)
4. distillationThe solvent was distilled off
5. customto afford the product in 91% yield (1.5 g)
6. customObserved mass 130.1 [M+H+] (rt: 0.26 min)