反应详情

The solution of ethyl 2-morpholinoacetate (1 g, 57.8 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 96.3% yield (0.8 g). LC-MS (ESI): Calculated mass: 145.16; Observed mass: 146.3 [M+H]+ (rt: 0.21 min).

1. concentrationThe mixture was concentrated
2. customquenched
3. extractionextracted as in Intermediate Example 15(b)
4. distillationThe solvent was distilled off
5. customto afford the product in 96.3% yield (0.8 g)
6. custom146.3 [M+H]+ (rt: 0.21 min)