反应详情

The solution of ethyl 2-(piperidin-1-yl)acetate (1 g, 5.84 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 95% yield (0.8 g). LC-MS (ESI): Calculated mass: 143.1; Observed mass 144.4 [M+H]+ (rt: 0.21 min).

1. concentrationThe mixture was concentrated
2. customquenched
3. extractionextracted as in Intermediate Example 15(b)
4. distillationThe solvent was distilled off
5. customto afford the product in 95% yield (0.8 g)
6. customObserved mass 144.4 [M+H]+ (rt: 0.21 min)