Ethyl 4-ethyl-1-piperazineacetate → (4-ethylpiperazin-1-yl)acetic acid

Participants

Reaction Steps

The solution of ethyl 2-(4-ethylpiperazin-1-yl)acetate (1.3 g, 6.50 mmol, 1.0 eq) in 8 N HCl stirred at 95° C. for 16 h. The mixture was concentrated on vacuum pump, and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 54.5% yield (0.6 g).

Provenance & Evidence