反应详情

The solution of ethyl 2-(4-ethylpiperazin-1-yl)acetate (1.3 g, 6.50 mmol, 1.0 eq) in 8 N HCl stirred at 95° C. for 16 h. The mixture was concentrated on vacuum pump, and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 54.5% yield (0.6 g).

1. concentrationThe mixture was concentrated on vacuum pump
2. customquenched
3. extractionextracted as in Intermediate Example 15(b)
4. distillationThe solvent was distilled off
5. customto afford the product in 54.5% yield (0.6 g)